Adults with atopic dermatitis (AD) had a significantly higher prevalence of anxiety, depression, and obsessive-compulsive disorder (OCD) across all severities of the skin disorder, a large retrospective analysis showed. The strongest association was with OCD, which occurred almost 50% more often in patients with AD. Anxiety and depression were more modestly elevated (14% higher) but still significantly different from individuals without AD. Additionally, patients with mild or moderate AD had higher rates of autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, and suicide.