With pioneering ADHD data, Alkermes eyes orexin agonist as potential ‘company changer’ 

 ADHD in the News 2026-09-24


Following Takeda’s historic approval of the first orexin agonist with its narcolepsy treatment Orzeyful, Alkermes has followed up with pioneering data that looks to take the hyped drug class out of sleep disorders and into broader patient populations. The neuro specialist today shared that its mimic of the brain protein orexin, which regulates arousal and alertness, alleviated symptoms in a small phase 1b trial of 50 adults with attention deficit hyperactivity disorder (ADHD).