A large prospective study published in Brain Sciences has found that suboptimal maternal cholesterol levels, in particular low high-density lipoprotein (HDL) cholesterol, may increase the risk for attention-deficit/hyperactivity disorder (ADHD) in offspring. Yuelong Ji, MS, MSPH, of the Center on Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health in Baltimore, Maryland, and colleagues also found that the male fetus appears to be more vulnerable to maternal cholesterol levels.