The amount of off-label uses of atypical antipsychotic drugs (AAPs) prescribed for children with attention-deficit/hyperactivity disorder (ADHD) raises questions about the appropriateness of AAPs for this indication. In a recent study, investigators analyzed outpatient data from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey. They found that between 1993 and 2010, AAP prescriptions written for patients aged between 4 and 18 years grew significantly, and that two-thirds of these prescriptions were written for off-label indications.1