Summary: New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that blocks kappa opioid receptors (KOR). In mouse models with a rare mutation that causes dopamine to leak abnormally, KOR blockers reduced this leakage and restored normal behavior. This approach could offer safer treatment alternatives for conditions like ADHD, bipolar disorder, and autism, which are often linked to disrupted dopamine signaling. Importantly, the treatment did not affect animals without the mutation, suggesting targeted therapeutic potential with fewer side effects.