Key Takeaways: Hormonal fluctuations, especially estrogen, significantly affect ADHD symptoms and mood in women, interacting with dopamine levels in the brain. Clinicians should screen for ADHD in women with psychiatric vulnerabilities, considering hormonal influences on mood and cognition. Stimulant medication may help counteract low estrogen levels, improving ADHD and mood symptoms during hormonal changes. More research is needed on hormonal impacts on ADHD, including the effects of contraceptives and mood disorders in women.