Women who used valproate for seizure control during pregnancy had an increased risk of attention deficit-hyperactivity disorder (ADHD) in their children, a population-based study in Denmark found. Prenatal exposure to valproate was tied to a 48% increased risk of ADHD after adjusting for maternal psychiatric disease, maternal epilepsy, and other potential confounders, according to Jakob Christensen, MD, PhD, of Aarhus University Hospital, and colleagues.