These Two Stimulants Should Be Contraindicated During Pregnancy, Group Says

Consumer advocacy organization Public Citizen is sounding the alarm about potential risks for birth defects associated with modafinil (Provigil) and armodafinil (Nuvigil), two stimulants commonly prescribed during pregnancy. The group argued that animal toxicity studies and post-marketing observational studies have turned up sufficient evidence to justify additional precautions for pregnant patients.

Read More

Blocking Opioid Receptors May Restore Healthy Dopamine Balance

Summary: New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that blocks kappa opioid receptors (KOR). In mouse models with a rare mutation that causes dopamine to leak abnormally, KOR blockers reduced this leakage and restored normal behavior. This approach could offer safer treatment alternatives for conditions like…

Read More

Autism and ADHD have distinct brain connectivity signatures, study finds

[Excerpt] Researchers at the National Institutes of Health and King’s College London recently carried out a large-scale statistical analysis aimed at comparing the patterns of communication between different regions in the brains of individuals diagnosed with ASD with those observed in the brains of individuals with ADHD. Their findings, published in Nature Mental Health, suggest…

Read More

Centanafadine Effective, ‘Clinically Meaningful’ for Adult ADHD

LOS ANGELES — The novel norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) centanafadine (Otsuka Pharmaceutical Co., Ltd.) is effective and “clinically meaningful” for adult attention-deficit/hyperactivity disorder (ADHD), new research suggested. In a combined analysis of two phase 3 trials with a total of 859 adults, more patients who received the NDSRI had at least an…

Read More

Parenting Training Reduces Healthcare Needs for Kids With Asthma Plus ADHD

Key Takeaways: An intervention for parents of children with both asthma and ADHD reduced unscheduled healthcare visits compared with usual care. Asthma control improved significantly, as did parent-rated ADHD symptoms. The study was limited by its focus on families in Hong Kong, with unknown generalizability to U.S. care settings.

Read More